API Intermediates

1

Alogliptin Benzoate

Int-1

(R)-3-Boc-Amino piperidine

309956-78-3

2

Apixaban

N-1 Intermediate

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo piperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c] pyridine-3-carboxylate

503614-91-3

3

Apremilast

Acetamide Intermediate

Resolved Intermediate

N-(1,3-Dioxo-1,3-dihydroisobenzofuran-4-yl) acetamide 

(S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine

149690-12-0

149690-05-1

4

Atomoxetine Hcl

De methyl Hydroxy Intermediate

N,N-Dimethyl Oxalate Salt

3-(Methylamino)-1-phenylpropan-1-ol

N,N-dimethyl-3-phenyl-3-(o-tolyloxy)propan-1-amine oxalate

42142-52-9

107688-86-8

5

Azilsartan

Azilsartan Base

Ethoxy Compound

Azilsartan amidoxime (AZL-I)

Azilsartan ester (AZL-II)

1-[[2`-(4,5-Dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylic Acid

Methyl 3-((2′-cyanobiphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylate 

Methyl 2-ethoxy [[2`-(hydroxyamidino)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate

Methyl 1-[[2`-(4,5-dihydro-5-oxo-4H-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]methyl]-2-ethoxy-1H-benzimidazole-7-carboxylete

147403-03-0

139481-44-0

147403-65-4

147403-52-9

6

Blonanserin

Cyclized Intermediate

3-(Methylamino)-1-phenylpropan-1-ol

42142-52-9

7

Candesartan Cilexetil

Ethoxy Compound

Tetrazole Compound

Carboxylic Acid

Trityl Candesartan

Trityl Candesartan Cilexetil

Methyl 3-((2′-cyanobiphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylate

Methyl 3-((2′-(2H-tetrazol-5- yl)biphenyl-4-yl)methyl)-2-ethoxy-3H-benzo[d]imidazole-4-carboxylate

3-((2′-(2H-Tetrazol-5-yl)biphenyl-4-yl)methyl)-2-ethoxy 3H-benzo[d]imidazole-4-carboxylic acid

2-Ethoxy-1-{[2′-(1-triphenylmethyl-1H tetrazole-5-yl)biphenyl-4-yl]methyl}benzimidazole-7-carboxylic acid

1-(Cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-3-((2′-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl)-3H-benzo[d]imidazole-4-carboxylate

139481-44-0

139481-69-9

139481-59-7

139481-72-4

170791-09-0

8

Citalopram HBr

Cyano Diol

Cyano Diol HBr

Cyano Diol HCl

4-[4-(Dimethyl amino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyl methyl) benzonitrile

4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide

(4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrochloride)

103146-25-4

103146-25-4

717133-25-0

9

Clopidogrel Bisulphate

Int-1

Int-2

CLO-II

Clopi Pyridine

Clopidogrel Camphorsulfonate(CPG CSA)

D(+)-Chloro phenyl glycine methyl ester HCl

2-Thiophene ethanol tosyl ester

(S)-Methyl 2-(2-chlorophenyl)-2-((2-(thiophen-2-yl)ethyl)amino)acetate hydrochloride

Thieno[3,2-c]pyridine, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

S)-Methyl-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate(7,7-dimethyl-2-oxo bicyclo[2.2.1]heptan-1-yl) methanesulfonate

213018-92-9

40412-06-4

141109-19-5

28783-41-7

120202-68-8

10

Dabigatran Etexilate

CPA Intermediate

Amine Intermediate

Coupled Cyano Intermediate

Dabigatran

N-(4-cyano-phenyl)-glycogen

3-Amino-4-methylaminobenzoic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl) amide

1-Methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

1-Methyl-2-[N-(4-amidinophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylicacid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide

42288-26-6

212322-56-0

211915-84-3

429658-95-7

11

Duloxetine HCl

De methyl Resolved Hydroxy Intermediate

(S)-3-(N-Methylamino)-1-(2-thienyl) propan-1-ol

116539-55-0

12

Edoxaban

Edoxaban base

Edoxaban HCl

N-(5-Chloro-2-pyridinyl)-N’-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-ethanediamide

N-(5-Chloro-2-pyridinyl)-N’-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-ethanediamide-Hydrochloride

480449-70-5

480448-29-1

13

Escitalopram Oxalate

Cyano Diol

Cyano Diol HBr

Cyano Diol HCl

Resolved Salt

Escitalopram Base

4-[4-(Dimethyl amino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxyl methyl) benzonitrile

4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrobromide

(4-[4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)benzonitrile hydrochloride)

4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxy-1-butyl-3-hydroxymethyl-benzonitrile hemi -(+)-di-p-toluoyl-d-tartaric acid salt

(s)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5 carbonitrile

103146-25-4

103146-26-5

717133-25-0

717133-25-0

1332724-03-4

14

Ipragliflozin

Int-1

Ipragliflozin (N-1)

 2-(5-Bromo-2-fluorobenzyl) benzo[b]thiophene

(2R,3R,4R,5S,6S)-2-(Acetoxymethyl)-6-(3-(benzo[b]thiophen-2-ylmethyl)-4-fluorophenyl)-tetrahydro-2H-pyran-3,4,5-triyl triacetate

1034305-17-3

1034305-21-9

15

Escitalopram Oxalate

Lanso Sulphide

2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1Hbenzimidazole

103577-40-8

16

Levocitirizine Di HCl

Benzhydryl piperazine

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

300543-56-0

17

Linagliptin

Bromo Intermediate

Coupled Intermediate

8-Bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

8-Bromo-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl) methyl)-1H-purine-2,6(3H,7H)-dione

666816-98-4

853029-57-9

18

Linezolid

Carbamate Intermediate

Phthalimide Intermediate

Deacetamide Linezolid Phthalimide (Coupled compound)

N-(Ethoxy carbonyl)-3-fluoro-4-morpholinyl aniline

(S)-Glycidyl pthalimide

(S)-N-[(3-[3-Fluoro-4-[4-morpholinyl] phenyl-2-oxo-5-oxazolidinyl]methyl] phthalimide

565176-83-2

161596-47-0

168828-89-5

19

Losartan potassium

Cyano Alcohol

Losartan Base

4’-[(2-butyl-4-chloro-5-hydroxymethyl)-1H-imidazol-1-yl)methyl]-[1,1’-Biphenyl]-2-carbonitrile

2-Butyl-4-chloro-1-[(2’-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole

114772-55-3

114798-26-4

20

Memantine Hcl

Br-DMA

941-37-7

565176-83-2

21

Mirabegron

Amine compound 

Nitro compound

(R)-2-(4-Amino phenethylamino)-1-phenylethanol

(R)-2-(4-Nitro phenethylamino)-1-phenylethanol . HCl

391901-45-4

521284-21-9

22

Omeprazole

Ome Sulphide

5-Methoxy-2[[(3,5-dimethyl-4-methoxy pyridinyl)-methyl]thio]-1Hbenzimidazole

73590-85-9

23

Olanzapine

Olanzapine Cyclic Hcl

Olanzapine Nitro

4-amino-2-methyl-10h-thieno [2,3-b] [1,5] benzodiazepine hydrochloride

5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile

138564-60-0

138564-59-7

24

Olmesartan Medoxomil

Diethyl Ester

EPIC

Trityl Olmesartan

Trityl Olmesartan Medoxomil

Diethyl 2-Propylimidazole-4,5-dicarboxylate

Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate

4-(1-Hydroxy-1-methylethyl)-2-propyl-{4-[2-(trityltetrazol-5-yl)phenyl] phenyl} methylimidazole-5-carboxylicacid

(5-Methyl-2-oxo -1,3-dioxolen-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate

144689-94-1

144689-93-0

761404-85-7

144690-92-6

25

Paliperidone

Ketobase

3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

130049-82-0

26

Pantoprazole Sodium

Pantoprazole Sulphide

Pantoprazole Base

5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)-methyl]thio]-1H-benzimidazole

6-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole

102625-64-9

102625-70-7

27

Pioglitazone.HCl

Pio Thiozole Base

14. (Z)-5-(4-(2-(5-Ethylpyridin-2- yl)ethoxy)benzylidene)thiazolidine-2,4-dione

144809-28-9

28

Posaconazole

Phenyl Carbamate Intermediate

Benzyloxy Pentane Intermediate

O-Benzyl Posaconazole Intermediate

Phenyl 4-(4-(4-hydroxyphenyl)piperazin-1-yl) phenylcarbamate (Phenyl carbamate)

2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl) piperazin-1-yl)phenyl)-2H-1,2,4-triazol-3(4H)-one (Benzyloxy pentane)

4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methoxy) phenyl) piperazin-1-yl)phenyl)-2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-2H-1,2,4-triazol-3(4H)-one (Benzyl posaconazole)

184177-81-9

184177-83-1

170985-86-1

29

Prasugrel

Pyridine Intermediate (CR-I)

THP-II

Cyclopropyl Intermediate

Prasugrel N-1 Intermediate

4,5,6,7-Tetrahydrothieno[3,2-c] pyridine hydrochloride

5,6,7,7a-Tetrahydrothieno[3,2-c] pyridin-2(4H)-one hydrochloride

2-Bromo-2-(2-fluorophenyl)-1-cyclopropyl ethanone

5-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrobromide

28783-41-7

115473-15-9

204205-33-4

150322-38-6

30

Ranolazine

RAN-II

RIN-I

1-[(2,6-Dimethylphenyl)-aminocarbonylmethyl]piperazine

1-(2-Methoxyphenoxy)-2,3-epoxypropane

5294-61-1

2210-74-4

31

Risperidone

F-BIP Hcl

F-BIP

CLMTPP

CLMTPP Hcl

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole HCl

6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole

3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

(3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride)

84163-13-3

84163-77-9

95742-20-4

93076-03-0

32

Rivaroxaban

Int-1

Int-2

Int-3

(S)-2-(2-hydroxy-3-(4-(3-oxomorpholino) phenylamino)propyl)isoindoline-1,3-dione

(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl) oxazolidin-5-yl)methyl)isoindoline-1,3-dione

(S)-(2-oxo-3-(4-(3-oxomorpholino)phenyl) oxazolidin-5-yl)methanaminium chloride

1369969-44-7

446292-08-6

33

Rosuvastatin Calcium

Rosuvastatin Coupled

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

289042-12-2

34

Rupatadine Fumarate

Chloro Intermediate

3-(Chloromethyl)-5-methylpyridine hydrochloride

1007089-84-0

35

Sacubitril Sodium

Ethyl Ester Intermediate

 (2S)-Ethyl 4-amino-5-(biphenyl-4-yl)-2-methylpentanoate hydrochloride

149690-12-0

36

Saxagliptin

Saxagliptin.HCl

(1S,3S,5S)-2-[(2S)-Amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride

709031-78-7

37

Sildenafil Citrate

Sil Amide

Sil Amine Hcl

Sil Coupled

Sil Cyclized

Sil Chlorosulphonyl

Sildenafil Base

4-Nitro-1-methyl-3n-propyl pyrazole-5-carboxamide

4-Amino-1-methyl-3n-propylpyrazole-5-carboxamide Hcl

4-[(2-Ethoxyphenyl) carbonylamino]-1-methyl-3npropylpyrazole-5-carboxamide

5-(2-Ethoxyphenyl)-1-methyl-3-propyl-6-hydropyrazolo[4,5-d]pyrimidine-7-one

5-(5-Chlorosulfonyl-2-ethoxyphenyl)-1-methyl-3n-propyl-1,6-dihydro-7H-pyrazolo-[4,3-d]-pyrimidin-7-one

1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine

139756-01-7

247584-10-7

139756-03-9

139756-21-1

139756-22-2

139755-83-2

38

Sumatriptan Succinate

Sumatriptan Base

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide

103628-46-2

39

Valsartan

Trityl valsartan Methyl Ester

Valsartan Barium Salt (VS-I)

3-Methyl-2-(N-((2′-(2-trityl-2,5-dihydro-1H-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)butanoic acid

N-(1-Oxopentyl)-N-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]- L-valine barium salt

195435-23-5

40

Valsartan Sacubitril Sodium

 Crystalline Form

Amorphous

Tri sodium salt of [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbmoyl) propionate-(S)-3′-methyl-2′-(pentanoyl-{2″-(tetrazol-5-ylate)biphenyl-4′-yl methyl}amino)butyrate]

Tri sodium salt of [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbmoyl) propionate-(S)-3′-methyl-2′-(pentanoyl-{2″-(tetrazol-5-ylate)biphenyl-4′-yl methyl}amino)butyrate]

936623-90-4

936623-90-4